Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction

Cardiac fibrosis is critically involved in the adverse remodeling accompanying dilated cardiomyopathies (DCMs), which leads to cardiac dysfunction and heart failure (HF). Connective tissue growth factor (CTGF), a profibrotic cytokine, plays a key role in this deleterious process. Some beneficial eff...

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Detalles Bibliográficos
Autores principales: Touvron, Melissa, Escoubet, Brigitte, Mericskay, Mathias, Angelini, Aude, Lamotte, Luciane, Santini, Maria Paola, Rosenthal, Nadia, Daegelen, Dominique, Tuil, David, Decaux, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380711/
https://www.ncbi.nlm.nih.gov/pubmed/22563064
http://dx.doi.org/10.1242/dmm.009456

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