Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands. Applying this method to primary human bone marrow specimens from pat...

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Detalles Bibliográficos
Autores principales: Akalin, Altuna, Garrett-Bakelman, Francine E., Kormaksson, Matthias, Busuttil, Jennifer, Zhang, Lu, Khrebtukova, Irina, Milne, Thomas A., Huang, Yongsheng, Biswas, Debabrata, Hess, Jay L., Allis, C. David, Roeder, Robert G., Valk, Peter J. M., Löwenberg, Bob, Delwel, Ruud, Fernandez, Hugo F., Paietta, Elisabeth, Tallman, Martin S., Schroth, Gary P., Mason, Christopher E., Melnick, Ari, Figueroa, Maria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380828/
https://www.ncbi.nlm.nih.gov/pubmed/22737091
http://dx.doi.org/10.1371/journal.pgen.1002781

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