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Protein Scaffolds Can Enhance the Bistability of Multisite Phosphorylation Systems

The phosphorylation of a substrate at multiple sites is a common protein modification that can give rise to important structural and electrostatic changes. Scaffold proteins can enhance protein phosphorylation by facilitating an interaction between a protein kinase enzyme and its target substrate. I...

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Detalles Bibliográficos
Autores principales: Chan, Carlo, Liu, Xinfeng, Wang, Liming, Bardwell, Lee, Nie, Qing, Enciso, Germán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380838/
https://www.ncbi.nlm.nih.gov/pubmed/22737061
http://dx.doi.org/10.1371/journal.pcbi.1002551