A Mouse Model of Acrodermatitis Enteropathica: Loss of Intestine Zinc Transporter ZIP4 (Slc39a4) Disrupts the Stem Cell Niche and Intestine Integrity

Mutations in the human Zip4 gene cause acrodermatitis enteropathica, a rare, pseudo-dominant, lethal genetic disorder. We created a tamoxifen-inducible, enterocyte-specific knockout of this gene in mice which mimics this human disorder. We found that the enterocyte Zip4 gene in mice is essential thr...

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Detalles Bibliográficos
Autores principales: Geiser, Jim, Venken, Koen J. T., De Lisle, Robert C., Andrews, Glen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380849/
https://www.ncbi.nlm.nih.gov/pubmed/22737083
http://dx.doi.org/10.1371/journal.pgen.1002766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380849/
https://www.ncbi.nlm.nih.gov/pubmed/22737083
http://dx.doi.org/10.1371/journal.pgen.1002766

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