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Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation

Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals. Here we show that simvastatin significantly increased the mean and maximum lifespan of Drosophila melanoga...

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Detalles Bibliográficos
Autores principales:	Spindler, Stephen R., Li, Rui, Dhahbi, Joseph M., Yamakawa, Amy, Mote, Patricia, Bodmer, Rolf, Ocorr, Karen, Williams, Renee T., Wang, Yinsheng, Ablao, Kenneth P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380867/ https://www.ncbi.nlm.nih.gov/pubmed/22737247 http://dx.doi.org/10.1371/journal.pone.0039581

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