Cargando…
A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model
Stably suppressed viremia during ART is essential for establishing reliable simian models for HIV/AIDS. We tested the efficacy of a multidrug ART (highly intensified ART) in a wide range of viremic conditions (10(3)–10(7) viral RNA copies/mL) in SIVmac251-infected rhesus macaques, and its impact on...
Autores principales: | Shytaj, Iart Luca, Norelli, Sandro, Chirullo, Barbara, Della Corte, Alessandro, Collins, Matt, Yalley-Ogunro, Jake, Greenhouse, Jack, Iraci, Nunzio, Acosta, Edward P., Barreca, Maria Letizia, Lewis, Mark G., Savarino, Andrea |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380955/ https://www.ncbi.nlm.nih.gov/pubmed/22737073 http://dx.doi.org/10.1371/journal.ppat.1002774 |
Ejemplares similares
-
Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy
por: Lewis, Mark G, et al.
Publicado: (2010) -
Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques
por: Lewis, MG, et al.
Publicado: (2010) -
Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS
por: Shytaj, Iart Luca, et al.
Publicado: (2013) -
A scalable workflow to test “shock and kill” therapeutic approaches against the HIV-1 latent reservoir in blood cells ex vivo
por: Procopio, Francesco Andrea, et al.
Publicado: (2023) -
A cure for AIDS: a matter of timing?
por: Shytaj, Iart Luca, et al.
Publicado: (2013)