Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) and their aggregation impair normal cellular function and can be toxic, leading to cell death. Prolonged expression of misfolded proteins triggers ER stress, which initiates a cascade of reactions called the unfolded protein respon...

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Detalles Bibliográficos
Autores principales: Haeri, Mohammad, Knox, Barry E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ophthalmic Research Center 2012
Materias:
Translational Eye Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381108/
https://www.ncbi.nlm.nih.gov/pubmed/22737387

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