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Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease

PURPOSE: We aimed to determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in a large group of Korean patients with Behçet's disease (BD), with and without joint involvement, and to compare these findings with the prevalences of anti-CCP antibodies in patients with...

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Autores principales: Cho, Sung Bin, Lee, Ju Hee, Ahn, Keun Jae, Bae, Byung Gi, Kim, Taegyun, Park, Yong-Beom, Lee, Soo-Kon, Lee, Kwang Hoon, Bang, Dongsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381466/
https://www.ncbi.nlm.nih.gov/pubmed/22665343
http://dx.doi.org/10.3349/ymj.2012.53.4.759
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author Cho, Sung Bin
Lee, Ju Hee
Ahn, Keun Jae
Bae, Byung Gi
Kim, Taegyun
Park, Yong-Beom
Lee, Soo-Kon
Lee, Kwang Hoon
Bang, Dongsik
author_facet Cho, Sung Bin
Lee, Ju Hee
Ahn, Keun Jae
Bae, Byung Gi
Kim, Taegyun
Park, Yong-Beom
Lee, Soo-Kon
Lee, Kwang Hoon
Bang, Dongsik
author_sort Cho, Sung Bin
collection PubMed
description PURPOSE: We aimed to determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in a large group of Korean patients with Behçet's disease (BD), with and without joint involvement, and to compare these findings with the prevalences of anti-CCP antibodies in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). MATERIALS AND METHODS: We tested 189 patients with BD, 105 with RA, and 36 with SLE for anti-CCP antibodies and IgM rheumatoid factor in serum. We reviewed the medical records of patients with BD to investigate their personal and clinical characteristics as well as their laboratory test results. RESULTS: Anti-CCP antibodies were detected in seven of the 189 BD patients (3.7%), at a mean titer of 30.6±44.4 U/mL, in 86 of the 105 RA patients (81.9%) with a mean titer of 198.8±205.7 U/mL, and in nine of the 36 SLE patients (25%) with a mean titer of 180.4±113.9 U/mL. One of the seven anti-CCP-positive BD patients fulfilled the diagnostic criteria for both BD and RA. Five of the seven anti-CCP-positive BD patients (71.4%) had polyarticular joint involvement, and the other two patients (28.6%) had oligoarticular involvement. CONCLUSION: We determined the prevalence of anti-CCP antibodies in a large group of Korean BD patients with and without joint involvement. Negative anti-CCP test in patients with BD may help to differentiate BD from RA and SLE, all of which present with similar clinical features.
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spelling pubmed-33814662012-07-01 Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease Cho, Sung Bin Lee, Ju Hee Ahn, Keun Jae Bae, Byung Gi Kim, Taegyun Park, Yong-Beom Lee, Soo-Kon Lee, Kwang Hoon Bang, Dongsik Yonsei Med J Original Article PURPOSE: We aimed to determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in a large group of Korean patients with Behçet's disease (BD), with and without joint involvement, and to compare these findings with the prevalences of anti-CCP antibodies in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). MATERIALS AND METHODS: We tested 189 patients with BD, 105 with RA, and 36 with SLE for anti-CCP antibodies and IgM rheumatoid factor in serum. We reviewed the medical records of patients with BD to investigate their personal and clinical characteristics as well as their laboratory test results. RESULTS: Anti-CCP antibodies were detected in seven of the 189 BD patients (3.7%), at a mean titer of 30.6±44.4 U/mL, in 86 of the 105 RA patients (81.9%) with a mean titer of 198.8±205.7 U/mL, and in nine of the 36 SLE patients (25%) with a mean titer of 180.4±113.9 U/mL. One of the seven anti-CCP-positive BD patients fulfilled the diagnostic criteria for both BD and RA. Five of the seven anti-CCP-positive BD patients (71.4%) had polyarticular joint involvement, and the other two patients (28.6%) had oligoarticular involvement. CONCLUSION: We determined the prevalence of anti-CCP antibodies in a large group of Korean BD patients with and without joint involvement. Negative anti-CCP test in patients with BD may help to differentiate BD from RA and SLE, all of which present with similar clinical features. Yonsei University College of Medicine 2012-07-01 2012-05-22 /pmc/articles/PMC3381466/ /pubmed/22665343 http://dx.doi.org/10.3349/ymj.2012.53.4.759 Text en © Copyright: Yonsei University College of Medicine 2012 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cho, Sung Bin
Lee, Ju Hee
Ahn, Keun Jae
Bae, Byung Gi
Kim, Taegyun
Park, Yong-Beom
Lee, Soo-Kon
Lee, Kwang Hoon
Bang, Dongsik
Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease
title Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease
title_full Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease
title_fullStr Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease
title_full_unstemmed Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease
title_short Anti-Cyclic Citrullinated Peptide Antibodies and Joint Involvement in Behçet's Disease
title_sort anti-cyclic citrullinated peptide antibodies and joint involvement in behçet's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381466/
https://www.ncbi.nlm.nih.gov/pubmed/22665343
http://dx.doi.org/10.3349/ymj.2012.53.4.759
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