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Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults

Merkel cell polyomavirus (MCV) is a recently discovered virus that causes 80% of Merkel cell carcinomas. We examined data for 564 gay/bisexual male participants >18 years of age in the Multicenter AIDS Cohort Study in Pittsburgh, Pennsylvania, USA, and found that 447 (79.3%) were MCV-antibody pos...

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Autores principales: Tolstov, Yanis L., Knauer, Alycia, Chen, Jian Guo, Kensler, Thomas W., Kingsley, Lawrence A., Moore, Patrick S., Chang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381535/
https://www.ncbi.nlm.nih.gov/pubmed/21801612
http://dx.doi.org/10.3201/eid1708.110079
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author Tolstov, Yanis L.
Knauer, Alycia
Chen, Jian Guo
Kensler, Thomas W.
Kingsley, Lawrence A.
Moore, Patrick S.
Chang, Yuan
author_facet Tolstov, Yanis L.
Knauer, Alycia
Chen, Jian Guo
Kensler, Thomas W.
Kingsley, Lawrence A.
Moore, Patrick S.
Chang, Yuan
author_sort Tolstov, Yanis L.
collection PubMed
description Merkel cell polyomavirus (MCV) is a recently discovered virus that causes 80% of Merkel cell carcinomas. We examined data for 564 gay/bisexual male participants >18 years of age in the Multicenter AIDS Cohort Study in Pittsburgh, Pennsylvania, USA, and found that 447 (79.3%) were MCV-antibody positive at initial enrollment. Of the 117 MCV-seronegative men, 31 subsequently seroconverted over a 4-year follow-up period, corresponding to a 6.6% annual conversion rate. MCV immunoglobulin G levels remained detectable up to 25 years after exposure. No signs, symptoms, or routine diagnostic test results were associated with MCV infection, and no correlation between HIV infection or AIDS progression and MCV infection was noted. An initial correlation between chronic hepatitis B virus infection and MCV prevalence could not be confirmed among MCV seroconverters or in studies of a second hepatitis B virus–hyperendemic cohort from Qidong, China. In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations.
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spelling pubmed-33815352012-06-28 Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults Tolstov, Yanis L. Knauer, Alycia Chen, Jian Guo Kensler, Thomas W. Kingsley, Lawrence A. Moore, Patrick S. Chang, Yuan Emerg Infect Dis Research Merkel cell polyomavirus (MCV) is a recently discovered virus that causes 80% of Merkel cell carcinomas. We examined data for 564 gay/bisexual male participants >18 years of age in the Multicenter AIDS Cohort Study in Pittsburgh, Pennsylvania, USA, and found that 447 (79.3%) were MCV-antibody positive at initial enrollment. Of the 117 MCV-seronegative men, 31 subsequently seroconverted over a 4-year follow-up period, corresponding to a 6.6% annual conversion rate. MCV immunoglobulin G levels remained detectable up to 25 years after exposure. No signs, symptoms, or routine diagnostic test results were associated with MCV infection, and no correlation between HIV infection or AIDS progression and MCV infection was noted. An initial correlation between chronic hepatitis B virus infection and MCV prevalence could not be confirmed among MCV seroconverters or in studies of a second hepatitis B virus–hyperendemic cohort from Qidong, China. In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations. Centers for Disease Control and Prevention 2011-08 /pmc/articles/PMC3381535/ /pubmed/21801612 http://dx.doi.org/10.3201/eid1708.110079 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Tolstov, Yanis L.
Knauer, Alycia
Chen, Jian Guo
Kensler, Thomas W.
Kingsley, Lawrence A.
Moore, Patrick S.
Chang, Yuan
Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults
title Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults
title_full Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults
title_fullStr Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults
title_full_unstemmed Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults
title_short Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults
title_sort asymptomatic primary merkel cell polyomavirus infection among adults
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381535/
https://www.ncbi.nlm.nih.gov/pubmed/21801612
http://dx.doi.org/10.3201/eid1708.110079
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