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GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases

Increasing evidence suggests that multiple genes in the human leukocyte antigen (HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide...

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Autores principales: Shugart, Yin Yao, Wang, Ying, Jia, Wei-Hua, Zeng, Yi-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381606/
https://www.ncbi.nlm.nih.gov/pubmed/21439243
http://dx.doi.org/10.5732/cjc.011.10075
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author Shugart, Yin Yao
Wang, Ying
Jia, Wei-Hua
Zeng, Yi-Xin
author_facet Shugart, Yin Yao
Wang, Ying
Jia, Wei-Hua
Zeng, Yi-Xin
author_sort Shugart, Yin Yao
collection PubMed
description Increasing evidence suggests that multiple genes in the human leukocyte antigen (HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide association studies (GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other diseases. This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases.
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spelling pubmed-33816062012-06-25 GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases Shugart, Yin Yao Wang, Ying Jia, Wei-Hua Zeng, Yi-Xin Chin J Cancer Mini Review Increasing evidence suggests that multiple genes in the human leukocyte antigen (HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide association studies (GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other diseases. This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases. Sun Yat-sen University Cancer Center 2011-04 /pmc/articles/PMC3381606/ /pubmed/21439243 http://dx.doi.org/10.5732/cjc.011.10075 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Mini Review
Shugart, Yin Yao
Wang, Ying
Jia, Wei-Hua
Zeng, Yi-Xin
GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases
title GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases
title_full GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases
title_fullStr GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases
title_full_unstemmed GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases
title_short GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases
title_sort gwas signals across the hla regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381606/
https://www.ncbi.nlm.nih.gov/pubmed/21439243
http://dx.doi.org/10.5732/cjc.011.10075
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