Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant

β-Secretase, BACE1 is a neuron-specific membrane-associated protease that cleaves amyloid precursor protein (APP) to generate β-amyloid protein (Aβ). BACE1 is partially localized in lipid rafts. We investigated whether lipid raft localization of BACE1 affects Aβ production in neurons using a palmito...

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Detalles Bibliográficos
Autores principales: Motoki, Kazumi, Kume, Hideaki, Oda, Akiko, Tamaoka, Akira, Hosaka, Ai, Kametani, Fuyuki, Araki, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Inc 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381632/
https://www.ncbi.nlm.nih.gov/pubmed/22741101
http://dx.doi.org/10.1002/brb3.52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381632/
https://www.ncbi.nlm.nih.gov/pubmed/22741101
http://dx.doi.org/10.1002/brb3.52

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