Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconjugates which are either stable or cleavable in an aqueous, thiol-mediated reducing environment. The application of this methodology to reversible protein biotinylation, the irreversible labeling of pep...

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Detalles Bibliográficos
Autores principales: Ryan, Chris P., Smith, Mark E. B., Schumacher, Felix F., Grohmann, Dina, Papaioannou, Danai, Waksman, Gabriel, Werner, Finn, Baker, James R., Caddick, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2011
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381635/
https://www.ncbi.nlm.nih.gov/pubmed/21465057
http://dx.doi.org/10.1039/c1cc11114k

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