Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

Small noncoding RNAs (ncRNAs) have been shown to guide epigenetic silencing complexes to target loci in human cells. When targeted to gene promoters, these small RNAs can lead to long-term stable epigenetic silencing of gene transcription. To date, small RNAs have been shown to modulate transcriptio...

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Detalles Bibliográficos
Autores principales: Knowling, Stuart, Stapleton, Kenneth, Turner, Anne-Marie W, Uhlmann, Eugen, Lehmann, Thomas, Vollmer, Jörg, Morris, Kevin V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381641/
https://www.ncbi.nlm.nih.gov/pubmed/23343927
http://dx.doi.org/10.1038/mtna.2012.8

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