DNA Damage Response Pathway and Replication Fork Stress During Oligonucleotide Directed Gene Editing

Single-stranded DNA oligonucleotides (ODNs) can be used to direct the exchange of nucleotides in the genome of mammalian cells in a process known as gene editing. Once refined, gene editing should become a viable option for gene therapy and molecular medicine. Gene editing is regulated by a number o...

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Detalles Bibliográficos
Autores principales: Bonner, Melissa, Strouse, Bryan, Applegate, Mindy, Livingston, Paula, Kmiec, Eric B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381643/
https://www.ncbi.nlm.nih.gov/pubmed/23343929
http://dx.doi.org/10.1038/mtna.2012.9

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