Axonal transport of adeno-associated viral vectors is serotype-dependent

We have previously shown that AAV2 undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, like AAV2, it is also neuron-specific in rat brain....

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Autores principales: Salegio, Ernesto A., Samaranch, Lluis, Kells, Adrian P., Mittermeyer, Gabriele, San Sebastian, Waldy, Zhou, Shangzhen, Beyer, Janine, Forsayeth, John, Bankiewicz, Krystof S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381869/
https://www.ncbi.nlm.nih.gov/pubmed/22418061
http://dx.doi.org/10.1038/gt.2012.27
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author Salegio, Ernesto A.
Samaranch, Lluis
Kells, Adrian P.
Mittermeyer, Gabriele
San Sebastian, Waldy
Zhou, Shangzhen
Beyer, Janine
Forsayeth, John
Bankiewicz, Krystof S.
author_facet Salegio, Ernesto A.
Samaranch, Lluis
Kells, Adrian P.
Mittermeyer, Gabriele
San Sebastian, Waldy
Zhou, Shangzhen
Beyer, Janine
Forsayeth, John
Bankiewicz, Krystof S.
author_sort Salegio, Ernesto A.
collection PubMed
description We have previously shown that AAV2 undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, like AAV2, it is also neuron-specific in rat brain. Our findings show that axonal transport of AAV is serotype-dependent and this has implications for gene therapy of neurological diseases such as Huntington’s disease.
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spelling pubmed-33818692013-09-01 Axonal transport of adeno-associated viral vectors is serotype-dependent Salegio, Ernesto A. Samaranch, Lluis Kells, Adrian P. Mittermeyer, Gabriele San Sebastian, Waldy Zhou, Shangzhen Beyer, Janine Forsayeth, John Bankiewicz, Krystof S. Gene Ther Article We have previously shown that AAV2 undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, like AAV2, it is also neuron-specific in rat brain. Our findings show that axonal transport of AAV is serotype-dependent and this has implications for gene therapy of neurological diseases such as Huntington’s disease. 2012-03-15 2013-03 /pmc/articles/PMC3381869/ /pubmed/22418061 http://dx.doi.org/10.1038/gt.2012.27 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Salegio, Ernesto A.
Samaranch, Lluis
Kells, Adrian P.
Mittermeyer, Gabriele
San Sebastian, Waldy
Zhou, Shangzhen
Beyer, Janine
Forsayeth, John
Bankiewicz, Krystof S.
Axonal transport of adeno-associated viral vectors is serotype-dependent
title Axonal transport of adeno-associated viral vectors is serotype-dependent
title_full Axonal transport of adeno-associated viral vectors is serotype-dependent
title_fullStr Axonal transport of adeno-associated viral vectors is serotype-dependent
title_full_unstemmed Axonal transport of adeno-associated viral vectors is serotype-dependent
title_short Axonal transport of adeno-associated viral vectors is serotype-dependent
title_sort axonal transport of adeno-associated viral vectors is serotype-dependent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381869/
https://www.ncbi.nlm.nih.gov/pubmed/22418061
http://dx.doi.org/10.1038/gt.2012.27
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