Fusion to Snowdrop Lectin Magnifies the Oral Activity of Insecticidal ω-Hexatoxin-Hv1a Peptide by Enabling Its Delivery to the Central Nervous System

BACKGROUND: The spider-venom peptide ω-hexatoxin-Hv1a (Hv1a) targets insect voltage-gated calcium channels, acting directly at sites within the central nervous system. It is potently insecticidal when injected into a wide variety of insect pests, but it has limited oral toxicity. We examined the abi...

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Detalles Bibliográficos
Autores principales: Fitches, Elaine C., Pyati, Prashant, King, Glenn F., Gatehouse, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382250/
https://www.ncbi.nlm.nih.gov/pubmed/22761779
http://dx.doi.org/10.1371/journal.pone.0039389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382250/
https://www.ncbi.nlm.nih.gov/pubmed/22761779
http://dx.doi.org/10.1371/journal.pone.0039389

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