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CD154-CD40 interactions in the control of murine B cell hematopoiesis
Interactions between CD40 and CD154 play a very important role in control of immune responses, including the delivery of T cell help to B cells and other APCs. Thus far, there has been no role postulated for CD40-CD154 interactions in hematopoiesis. We show here that CD40 is expressed on murine pro-...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Leukocyte Biology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382295/ https://www.ncbi.nlm.nih.gov/pubmed/21330346 http://dx.doi.org/10.1189/jlb.0310179 |
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author | Carlring, Jennifer Altaher, Hala M. Clark, Susan Chen, Xi Latimer, Sarah L. Jenner, Tracey Buckle, Anne-Marie Heath, Andrew W. |
author_facet | Carlring, Jennifer Altaher, Hala M. Clark, Susan Chen, Xi Latimer, Sarah L. Jenner, Tracey Buckle, Anne-Marie Heath, Andrew W. |
author_sort | Carlring, Jennifer |
collection | PubMed |
description | Interactions between CD40 and CD154 play a very important role in control of immune responses, including the delivery of T cell help to B cells and other APCs. Thus far, there has been no role postulated for CD40-CD154 interactions in hematopoiesis. We show here that CD40 is expressed on murine pro-B cells and that its ligation enhances pro-B cell proliferation in vitro and in vivo. In addition, CD154 mRNA is present in the BM. Moreover, we show that a deficiency in CD154 expression has effects on B cell hematopoiesis. Aged, CD154-deficient mice have significantly lower levels of B hematopoietic subsets downstream of pro-B cells in the BM. In addition, B lineage cells reconstitute more slowly following BMT into CD154-deficient recipients. We hypothesize that CD154 is expressed by radio-resistant cells in the BM and plays a role in fine-tuning B cell hematopoiesis. |
format | Online Article Text |
id | pubmed-3382295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Society for Leukocyte Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-33822952012-07-10 CD154-CD40 interactions in the control of murine B cell hematopoiesis Carlring, Jennifer Altaher, Hala M. Clark, Susan Chen, Xi Latimer, Sarah L. Jenner, Tracey Buckle, Anne-Marie Heath, Andrew W. J Leukoc Biol Cell Development, Differentiation, & Trafficking Interactions between CD40 and CD154 play a very important role in control of immune responses, including the delivery of T cell help to B cells and other APCs. Thus far, there has been no role postulated for CD40-CD154 interactions in hematopoiesis. We show here that CD40 is expressed on murine pro-B cells and that its ligation enhances pro-B cell proliferation in vitro and in vivo. In addition, CD154 mRNA is present in the BM. Moreover, we show that a deficiency in CD154 expression has effects on B cell hematopoiesis. Aged, CD154-deficient mice have significantly lower levels of B hematopoietic subsets downstream of pro-B cells in the BM. In addition, B lineage cells reconstitute more slowly following BMT into CD154-deficient recipients. We hypothesize that CD154 is expressed by radio-resistant cells in the BM and plays a role in fine-tuning B cell hematopoiesis. Society for Leukocyte Biology 2011-05 /pmc/articles/PMC3382295/ /pubmed/21330346 http://dx.doi.org/10.1189/jlb.0310179 Text en © 2011 Society for Leukocyte Biology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cell Development, Differentiation, & Trafficking Carlring, Jennifer Altaher, Hala M. Clark, Susan Chen, Xi Latimer, Sarah L. Jenner, Tracey Buckle, Anne-Marie Heath, Andrew W. CD154-CD40 interactions in the control of murine B cell hematopoiesis |
title | CD154-CD40 interactions in the control of murine B cell hematopoiesis |
title_full | CD154-CD40 interactions in the control of murine B cell hematopoiesis |
title_fullStr | CD154-CD40 interactions in the control of murine B cell hematopoiesis |
title_full_unstemmed | CD154-CD40 interactions in the control of murine B cell hematopoiesis |
title_short | CD154-CD40 interactions in the control of murine B cell hematopoiesis |
title_sort | cd154-cd40 interactions in the control of murine b cell hematopoiesis |
topic | Cell Development, Differentiation, & Trafficking |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382295/ https://www.ncbi.nlm.nih.gov/pubmed/21330346 http://dx.doi.org/10.1189/jlb.0310179 |
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