Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target

Deregulation of cyclin-dependent kinases (CDKs) has been associated with many cancer types and has evoked an interest in chemical inhibitors with possible therapeutic benefit. While most known inhibitors display broad selectivity towards multiple CDKs, recent work highlights CDK9 as the critical tar...

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Detalles Bibliográficos
Autores principales: Kryštof, Vladimír, Baumli, Sonja, Fürst, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382371/
https://www.ncbi.nlm.nih.gov/pubmed/22571657
http://dx.doi.org/10.2174/138161212800672750
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author Kryštof, Vladimír
Baumli, Sonja
Fürst, Robert
author_facet Kryštof, Vladimír
Baumli, Sonja
Fürst, Robert
author_sort Kryštof, Vladimír
collection PubMed
description Deregulation of cyclin-dependent kinases (CDKs) has been associated with many cancer types and has evoked an interest in chemical inhibitors with possible therapeutic benefit. While most known inhibitors display broad selectivity towards multiple CDKs, recent work highlights CDK9 as the critical target responsible for the anticancer activity of clinically evaluated drugs. In this review, we discuss recent findings provided by structural biologists that may allow further development of highly specific inhibitors of CDK9 towards applications in cancer therapy. We also highlight the role of CDK9 in inflammatory processes and diseases.
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spelling pubmed-33823712012-06-27 Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target Kryštof, Vladimír Baumli, Sonja Fürst, Robert Curr Pharm Des Article Deregulation of cyclin-dependent kinases (CDKs) has been associated with many cancer types and has evoked an interest in chemical inhibitors with possible therapeutic benefit. While most known inhibitors display broad selectivity towards multiple CDKs, recent work highlights CDK9 as the critical target responsible for the anticancer activity of clinically evaluated drugs. In this review, we discuss recent findings provided by structural biologists that may allow further development of highly specific inhibitors of CDK9 towards applications in cancer therapy. We also highlight the role of CDK9 in inflammatory processes and diseases. Bentham Science Publishers 2012-07 2012-07 /pmc/articles/PMC3382371/ /pubmed/22571657 http://dx.doi.org/10.2174/138161212800672750 Text en © 2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Kryštof, Vladimír
Baumli, Sonja
Fürst, Robert
Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
title Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
title_full Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
title_fullStr Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
title_full_unstemmed Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
title_short Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
title_sort perspective of cyclin-dependent kinase 9 (cdk9) as a drug target
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382371/
https://www.ncbi.nlm.nih.gov/pubmed/22571657
http://dx.doi.org/10.2174/138161212800672750
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