The Cysteine-Rich Protein Thimet Oligopeptidase as a Model of the Structural Requirements for S-glutathiolation and Oxidative Oligomerization

Thimet oligopeptidase (EP24.15) is a cysteine-rich metallopeptidase containing fifteen Cys residues and no intra-protein disulfide bonds. Previous work on this enzyme revealed that the oxidative oligomerization of EP24.15 is triggered by S-glutathiolation at physiological GSSG levels (10–50 µM) via...

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Detalles Bibliográficos
Autores principales: Malvezzi, Alberto, Higa, Patrícia M., Amaral, Antonia T.-do, Silva, Gustavo M., Gozzo, Fabio C., Ferro, Emer S., Castro, Leandro M., de Rezende, Leandro, Monteiro, Gisele, Demasi, Marilene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382611/
https://www.ncbi.nlm.nih.gov/pubmed/22761783
http://dx.doi.org/10.1371/journal.pone.0039408

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