Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds

Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we ident...

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Autores principales: Philipp, Ute, Vollmar, Andrea, Häggström, Jens, Thomas, Anne, Distl, Ottmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382626/
https://www.ncbi.nlm.nih.gov/pubmed/22761652
http://dx.doi.org/10.1371/journal.pone.0036691
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author Philipp, Ute
Vollmar, Andrea
Häggström, Jens
Thomas, Anne
Distl, Ottmar
author_facet Philipp, Ute
Vollmar, Andrea
Häggström, Jens
Thomas, Anne
Distl, Ottmar
author_sort Philipp, Ute
collection PubMed
description Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.
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spelling pubmed-33826262012-07-03 Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds Philipp, Ute Vollmar, Andrea Häggström, Jens Thomas, Anne Distl, Ottmar PLoS One Research Article Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP. Public Library of Science 2012-06-25 /pmc/articles/PMC3382626/ /pubmed/22761652 http://dx.doi.org/10.1371/journal.pone.0036691 Text en Philipp et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Philipp, Ute
Vollmar, Andrea
Häggström, Jens
Thomas, Anne
Distl, Ottmar
Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds
title Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds
title_full Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds
title_fullStr Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds
title_full_unstemmed Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds
title_short Multiple Loci Are Associated with Dilated Cardiomyopathy in Irish Wolfhounds
title_sort multiple loci are associated with dilated cardiomyopathy in irish wolfhounds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382626/
https://www.ncbi.nlm.nih.gov/pubmed/22761652
http://dx.doi.org/10.1371/journal.pone.0036691
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