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Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States
Benzodiazepine use increases the risk of falls and has been associated with an increased risk of hip fractures. Our aim was to estimate the possible population impact of the use of benzodiazepines on the rate of hip fracture in France, Germany, Italy, Spain, the United Kingdom, and the United States...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382650/ https://www.ncbi.nlm.nih.gov/pubmed/22566242 http://dx.doi.org/10.1007/s00223-012-9603-8 |
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author | Khong, T. P. de Vries, F. Goldenberg, J. S. B. Klungel, O. H. Robinson, N. J. Ibáñez, Luisa Petri, H. |
author_facet | Khong, T. P. de Vries, F. Goldenberg, J. S. B. Klungel, O. H. Robinson, N. J. Ibáñez, Luisa Petri, H. |
author_sort | Khong, T. P. |
collection | PubMed |
description | Benzodiazepine use increases the risk of falls and has been associated with an increased risk of hip fractures. Our aim was to estimate the possible population impact of the use of benzodiazepines on the rate of hip fracture in France, Germany, Italy, Spain, the United Kingdom, and the United States. We conducted a literature review to estimate the pooled relative risk (RR) for hip fractures and use of benzodiazepines. Prevalence rates of benzodiazepine use in 2009 were calculated for each country using the IMS MIDAS database and three public databases in Denmark, the Netherlands, and Norway. Both the RR and prevalence rates were used for calculation of population attributable risks (PARs) of hip fractures associated with benzodiazepine use. The literature review showed an increased risk of hip fractures in benzodiazepine users (RR = 1.4, 95 % CI 1.2–1.6). Rate of benzodiazepine use showed considerable differences between countries, ranging from 4.7 % to 22.3 % of population ever in a 1-year period. These are reflected in results for the PARs; estimated attributions of benzodiazepines to the rate of hip fractures were 1.8 %, 95 % CI 1.1–2.6 (Germany); 2.0 %, 95 % CI 1.2–2.8 (United Kingdom); 5.2 %, 95 % CI 3.2–7.3 (Italy); 7.4 %, 95 % CI 4.5–10.0 (France); 8.0 %, 95 % CI 4.9–11.0 (United States); and 8.2 %, 95 % CI 5.1–12.0 (Spain). PAR estimates suggest that the potential attribution of benzodiazepine use on the population rate of hip fractures in the five specified European countries and the United States varies between 1.8 % and 8.2 %. During the next phase of the IMI-PROTECT study, a comparison with individual patient data will show whether this approach is valid. |
format | Online Article Text |
id | pubmed-3382650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33826502012-07-05 Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States Khong, T. P. de Vries, F. Goldenberg, J. S. B. Klungel, O. H. Robinson, N. J. Ibáñez, Luisa Petri, H. Calcif Tissue Int Original Research Benzodiazepine use increases the risk of falls and has been associated with an increased risk of hip fractures. Our aim was to estimate the possible population impact of the use of benzodiazepines on the rate of hip fracture in France, Germany, Italy, Spain, the United Kingdom, and the United States. We conducted a literature review to estimate the pooled relative risk (RR) for hip fractures and use of benzodiazepines. Prevalence rates of benzodiazepine use in 2009 were calculated for each country using the IMS MIDAS database and three public databases in Denmark, the Netherlands, and Norway. Both the RR and prevalence rates were used for calculation of population attributable risks (PARs) of hip fractures associated with benzodiazepine use. The literature review showed an increased risk of hip fractures in benzodiazepine users (RR = 1.4, 95 % CI 1.2–1.6). Rate of benzodiazepine use showed considerable differences between countries, ranging from 4.7 % to 22.3 % of population ever in a 1-year period. These are reflected in results for the PARs; estimated attributions of benzodiazepines to the rate of hip fractures were 1.8 %, 95 % CI 1.1–2.6 (Germany); 2.0 %, 95 % CI 1.2–2.8 (United Kingdom); 5.2 %, 95 % CI 3.2–7.3 (Italy); 7.4 %, 95 % CI 4.5–10.0 (France); 8.0 %, 95 % CI 4.9–11.0 (United States); and 8.2 %, 95 % CI 5.1–12.0 (Spain). PAR estimates suggest that the potential attribution of benzodiazepine use on the population rate of hip fractures in the five specified European countries and the United States varies between 1.8 % and 8.2 %. During the next phase of the IMI-PROTECT study, a comparison with individual patient data will show whether this approach is valid. Springer-Verlag 2012-05-08 2012 /pmc/articles/PMC3382650/ /pubmed/22566242 http://dx.doi.org/10.1007/s00223-012-9603-8 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Research Khong, T. P. de Vries, F. Goldenberg, J. S. B. Klungel, O. H. Robinson, N. J. Ibáñez, Luisa Petri, H. Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States |
title | Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States |
title_full | Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States |
title_fullStr | Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States |
title_full_unstemmed | Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States |
title_short | Potential Impact of Benzodiazepine Use on the Rate of Hip Fractures in Five Large European Countries and the United States |
title_sort | potential impact of benzodiazepine use on the rate of hip fractures in five large european countries and the united states |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382650/ https://www.ncbi.nlm.nih.gov/pubmed/22566242 http://dx.doi.org/10.1007/s00223-012-9603-8 |
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