Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel

Recently, applications of the patch-clamp fluorometry (PCF) technique in studies of cyclic nucleotide–gated (CNG) and hyperpolarization-activated, cyclic nucleotide–regulated (HCN) channels have provided direct evidence for the long-held notion that ligands preferably bind to and stabilize these cha...

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Detalles Bibliográficos
Autores principales: Wu, Shengjun, Gao, Weihua, Xie, Changan, Xu, Xinping, Vorvis, Christina, Marni, Farzana, Hackett, Amber R., Liu, Qinglian, Zhou, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382721/
https://www.ncbi.nlm.nih.gov/pubmed/22689828
http://dx.doi.org/10.1085/jgp.201110749

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