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Combined Structure-Based Pharmacophore and 3D-QSAR Studies on Phenylalanine Series Compounds as TPH1 Inhibitors

Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. As a neurotransmitter, serotonin plays important physiological roles both peripherally and centrally. In this study, a combination of ligand-based and structure-based methods is used to clarify the essential quantitative...

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Detalles Bibliográficos
Autores principales:	Ouyang, Liang, He, Gu, Huang, Wei, Song, Xiangrong, Wu, Fengbo, Xiang, Mingli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382768/ https://www.ncbi.nlm.nih.gov/pubmed/22754301 http://dx.doi.org/10.3390/ijms13055348

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