Cargando…

The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability

Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instabil...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshioka, Ken-ichi, Atsumi, Yuko, Fukuda, Hirokazu, Masutani, Mitsuko, Teraoka, Hirobumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382772/
https://www.ncbi.nlm.nih.gov/pubmed/22754379
http://dx.doi.org/10.3390/ijms13056492
_version_ 1782236544769196032
author Yoshioka, Ken-ichi
Atsumi, Yuko
Fukuda, Hirokazu
Masutani, Mitsuko
Teraoka, Hirobumi
author_facet Yoshioka, Ken-ichi
Atsumi, Yuko
Fukuda, Hirokazu
Masutani, Mitsuko
Teraoka, Hirobumi
author_sort Yoshioka, Ken-ichi
collection PubMed
description Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instability and mutations are generated during the process of cellular transformation and how the development of genomic instability contributes to cellular transformation. Recent studies of cellular regulation and tetraploidy development have provided insights into the factors triggering cellular transformation and the regulatory mechanisms that protect chromosomes from genomic instability.
format Online
Article
Text
id pubmed-3382772
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-33827722012-06-29 The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability Yoshioka, Ken-ichi Atsumi, Yuko Fukuda, Hirokazu Masutani, Mitsuko Teraoka, Hirobumi Int J Mol Sci Review Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instability and mutations are generated during the process of cellular transformation and how the development of genomic instability contributes to cellular transformation. Recent studies of cellular regulation and tetraploidy development have provided insights into the factors triggering cellular transformation and the regulatory mechanisms that protect chromosomes from genomic instability. Molecular Diversity Preservation International (MDPI) 2012-05-24 /pmc/articles/PMC3382772/ /pubmed/22754379 http://dx.doi.org/10.3390/ijms13056492 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Yoshioka, Ken-ichi
Atsumi, Yuko
Fukuda, Hirokazu
Masutani, Mitsuko
Teraoka, Hirobumi
The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
title The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
title_full The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
title_fullStr The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
title_full_unstemmed The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
title_short The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
title_sort quiescent cellular state is arf/p53-dependent and associated with h2ax downregulation and genome stability
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382772/
https://www.ncbi.nlm.nih.gov/pubmed/22754379
http://dx.doi.org/10.3390/ijms13056492
work_keys_str_mv AT yoshiokakenichi thequiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT atsumiyuko thequiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT fukudahirokazu thequiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT masutanimitsuko thequiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT teraokahirobumi thequiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT yoshiokakenichi quiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT atsumiyuko quiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT fukudahirokazu quiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT masutanimitsuko quiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability
AT teraokahirobumi quiescentcellularstateisarfp53dependentandassociatedwithh2axdownregulationandgenomestability