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The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instabil...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382772/ https://www.ncbi.nlm.nih.gov/pubmed/22754379 http://dx.doi.org/10.3390/ijms13056492 |
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author | Yoshioka, Ken-ichi Atsumi, Yuko Fukuda, Hirokazu Masutani, Mitsuko Teraoka, Hirobumi |
author_facet | Yoshioka, Ken-ichi Atsumi, Yuko Fukuda, Hirokazu Masutani, Mitsuko Teraoka, Hirobumi |
author_sort | Yoshioka, Ken-ichi |
collection | PubMed |
description | Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instability and mutations are generated during the process of cellular transformation and how the development of genomic instability contributes to cellular transformation. Recent studies of cellular regulation and tetraploidy development have provided insights into the factors triggering cellular transformation and the regulatory mechanisms that protect chromosomes from genomic instability. |
format | Online Article Text |
id | pubmed-3382772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-33827722012-06-29 The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability Yoshioka, Ken-ichi Atsumi, Yuko Fukuda, Hirokazu Masutani, Mitsuko Teraoka, Hirobumi Int J Mol Sci Review Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instability and mutations are generated during the process of cellular transformation and how the development of genomic instability contributes to cellular transformation. Recent studies of cellular regulation and tetraploidy development have provided insights into the factors triggering cellular transformation and the regulatory mechanisms that protect chromosomes from genomic instability. Molecular Diversity Preservation International (MDPI) 2012-05-24 /pmc/articles/PMC3382772/ /pubmed/22754379 http://dx.doi.org/10.3390/ijms13056492 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Yoshioka, Ken-ichi Atsumi, Yuko Fukuda, Hirokazu Masutani, Mitsuko Teraoka, Hirobumi The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability |
title | The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability |
title_full | The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability |
title_fullStr | The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability |
title_full_unstemmed | The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability |
title_short | The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability |
title_sort | quiescent cellular state is arf/p53-dependent and associated with h2ax downregulation and genome stability |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382772/ https://www.ncbi.nlm.nih.gov/pubmed/22754379 http://dx.doi.org/10.3390/ijms13056492 |
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