Aβ-40 Y10F Increases βfibrils Formation but Attenuates the Neurotoxicity of Amyloid-β Peptide

Alzheimer’s disease (AD) is characterized by the abnormal aggregation of amyloid-β peptide (Aβ) in extracellular deposits known as senile plaques. The tyrosine residue (Tyr-10) is believed to be important in Aβ-induced neurotoxicity due to the formation of tyrosyl radicals. To reduce the likelihood...

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Detalles Bibliográficos
Autores principales: Dai, Xueling, Chang, Ping, Liu, Wenjuan, Xu, Ke, Sun, Yaxuan, Zhu, Shigong, Jiang, Zhaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382774/
https://www.ncbi.nlm.nih.gov/pubmed/22754299
http://dx.doi.org/10.3390/ijms13055324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382774/
https://www.ncbi.nlm.nih.gov/pubmed/22754299
http://dx.doi.org/10.3390/ijms13055324

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