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Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice

The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and org...

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Autores principales: Chen, Xiaoqiang, Ye, Sudan, Zhang, Shikang, Li, Jianrong, Zhu, Hongying, Zheng, Gaoli, Lu, Yin, Wan, Haitong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382803/
https://www.ncbi.nlm.nih.gov/pubmed/22754354
http://dx.doi.org/10.3390/ijms13056129
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author Chen, Xiaoqiang
Ye, Sudan
Zhang, Shikang
Li, Jianrong
Zhu, Hongying
Zheng, Gaoli
Lu, Yin
Wan, Haitong
author_facet Chen, Xiaoqiang
Ye, Sudan
Zhang, Shikang
Li, Jianrong
Zhu, Hongying
Zheng, Gaoli
Lu, Yin
Wan, Haitong
author_sort Chen, Xiaoqiang
collection PubMed
description The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P < 0.01). The result of tests of anti-GAD antibody suggested that FTY720 treatment could suppress the anti-GAD response.
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spelling pubmed-33828032012-06-29 Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice Chen, Xiaoqiang Ye, Sudan Zhang, Shikang Li, Jianrong Zhu, Hongying Zheng, Gaoli Lu, Yin Wan, Haitong Int J Mol Sci Article The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P < 0.01). The result of tests of anti-GAD antibody suggested that FTY720 treatment could suppress the anti-GAD response. Molecular Diversity Preservation International (MDPI) 2012-05-18 /pmc/articles/PMC3382803/ /pubmed/22754354 http://dx.doi.org/10.3390/ijms13056129 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chen, Xiaoqiang
Ye, Sudan
Zhang, Shikang
Li, Jianrong
Zhu, Hongying
Zheng, Gaoli
Lu, Yin
Wan, Haitong
Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice
title Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice
title_full Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice
title_fullStr Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice
title_full_unstemmed Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice
title_short Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice
title_sort effect of fty720 on some physiological indexes of non-obese diabetic (nod) mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382803/
https://www.ncbi.nlm.nih.gov/pubmed/22754354
http://dx.doi.org/10.3390/ijms13056129
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