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Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia

Diverse plants of ethnobotanic interest in Amazonia are commonly used in traditional medicine. We determined the antioxidant potential against lipid peroxidation, the antimicrobial activity, and the polyphenol composition of several Amazonian plants (Brownea rosademonte, Piper glandulosissimum, Pipe...

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Autores principales: Lizcano, Leandro J., Viloria-Bernal, María, Vicente, Francisca, Berrueta, Luis Angel, Gallo, Blanca, Martínez-Cañamero, Magdalena, Ruiz-Larrea, Maria Begoña, Ruiz-Sanz, José Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382806/
https://www.ncbi.nlm.nih.gov/pubmed/22754307
http://dx.doi.org/10.3390/ijms13055454
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author Lizcano, Leandro J.
Viloria-Bernal, María
Vicente, Francisca
Berrueta, Luis Angel
Gallo, Blanca
Martínez-Cañamero, Magdalena
Ruiz-Larrea, Maria Begoña
Ruiz-Sanz, José Ignacio
author_facet Lizcano, Leandro J.
Viloria-Bernal, María
Vicente, Francisca
Berrueta, Luis Angel
Gallo, Blanca
Martínez-Cañamero, Magdalena
Ruiz-Larrea, Maria Begoña
Ruiz-Sanz, José Ignacio
author_sort Lizcano, Leandro J.
collection PubMed
description Diverse plants of ethnobotanic interest in Amazonia are commonly used in traditional medicine. We determined the antioxidant potential against lipid peroxidation, the antimicrobial activity, and the polyphenol composition of several Amazonian plants (Brownea rosademonte, Piper glandulosissimum, Piper krukoffii, Piper putumayoense, Solanum grandiflorum, and Vismia baccifera). Extracts from the plant leaf, bark, and stem were prepared as aqueous infusions, as used in folk medicine, and added to rat liver microsomes exposed to iron. The polyphenolic composition was detected by reverse-phase HPLC coupled to diode-array detector and MS/MS analysis. The antimicrobial activity was tested by the spot-on-a-lawn method against several indicator microorganisms. All the extracts inhibited lipid oxidation, except the P. glandulosissimum stem. The plant extracts exhibiting high antioxidant potential (V. baccifera and B. rosademonte) contained high levels of flavanols (particularly, catechin and epicatechin). By contrast, S. grandiflorum leaf, which exhibited very low antioxidant activity, was rich in hydroxycinnamic acids. None of the extracts showed antimicrobial activity. This study demonstrates for the first time the presence of bioactive polyphenolic compounds in several Amazonian plants, and highlights the importance of flavanols as major phenolic contributors to antioxidant activity.
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spelling pubmed-33828062012-06-29 Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia Lizcano, Leandro J. Viloria-Bernal, María Vicente, Francisca Berrueta, Luis Angel Gallo, Blanca Martínez-Cañamero, Magdalena Ruiz-Larrea, Maria Begoña Ruiz-Sanz, José Ignacio Int J Mol Sci Article Diverse plants of ethnobotanic interest in Amazonia are commonly used in traditional medicine. We determined the antioxidant potential against lipid peroxidation, the antimicrobial activity, and the polyphenol composition of several Amazonian plants (Brownea rosademonte, Piper glandulosissimum, Piper krukoffii, Piper putumayoense, Solanum grandiflorum, and Vismia baccifera). Extracts from the plant leaf, bark, and stem were prepared as aqueous infusions, as used in folk medicine, and added to rat liver microsomes exposed to iron. The polyphenolic composition was detected by reverse-phase HPLC coupled to diode-array detector and MS/MS analysis. The antimicrobial activity was tested by the spot-on-a-lawn method against several indicator microorganisms. All the extracts inhibited lipid oxidation, except the P. glandulosissimum stem. The plant extracts exhibiting high antioxidant potential (V. baccifera and B. rosademonte) contained high levels of flavanols (particularly, catechin and epicatechin). By contrast, S. grandiflorum leaf, which exhibited very low antioxidant activity, was rich in hydroxycinnamic acids. None of the extracts showed antimicrobial activity. This study demonstrates for the first time the presence of bioactive polyphenolic compounds in several Amazonian plants, and highlights the importance of flavanols as major phenolic contributors to antioxidant activity. Molecular Diversity Preservation International (MDPI) 2012-05-04 /pmc/articles/PMC3382806/ /pubmed/22754307 http://dx.doi.org/10.3390/ijms13055454 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lizcano, Leandro J.
Viloria-Bernal, María
Vicente, Francisca
Berrueta, Luis Angel
Gallo, Blanca
Martínez-Cañamero, Magdalena
Ruiz-Larrea, Maria Begoña
Ruiz-Sanz, José Ignacio
Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia
title Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia
title_full Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia
title_fullStr Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia
title_full_unstemmed Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia
title_short Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia
title_sort lipid oxidation inhibitory effects and phenolic composition of aqueous extracts from medicinal plants of colombian amazonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382806/
https://www.ncbi.nlm.nih.gov/pubmed/22754307
http://dx.doi.org/10.3390/ijms13055454
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