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Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia
Diverse plants of ethnobotanic interest in Amazonia are commonly used in traditional medicine. We determined the antioxidant potential against lipid peroxidation, the antimicrobial activity, and the polyphenol composition of several Amazonian plants (Brownea rosademonte, Piper glandulosissimum, Pipe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382806/ https://www.ncbi.nlm.nih.gov/pubmed/22754307 http://dx.doi.org/10.3390/ijms13055454 |
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author | Lizcano, Leandro J. Viloria-Bernal, María Vicente, Francisca Berrueta, Luis Angel Gallo, Blanca Martínez-Cañamero, Magdalena Ruiz-Larrea, Maria Begoña Ruiz-Sanz, José Ignacio |
author_facet | Lizcano, Leandro J. Viloria-Bernal, María Vicente, Francisca Berrueta, Luis Angel Gallo, Blanca Martínez-Cañamero, Magdalena Ruiz-Larrea, Maria Begoña Ruiz-Sanz, José Ignacio |
author_sort | Lizcano, Leandro J. |
collection | PubMed |
description | Diverse plants of ethnobotanic interest in Amazonia are commonly used in traditional medicine. We determined the antioxidant potential against lipid peroxidation, the antimicrobial activity, and the polyphenol composition of several Amazonian plants (Brownea rosademonte, Piper glandulosissimum, Piper krukoffii, Piper putumayoense, Solanum grandiflorum, and Vismia baccifera). Extracts from the plant leaf, bark, and stem were prepared as aqueous infusions, as used in folk medicine, and added to rat liver microsomes exposed to iron. The polyphenolic composition was detected by reverse-phase HPLC coupled to diode-array detector and MS/MS analysis. The antimicrobial activity was tested by the spot-on-a-lawn method against several indicator microorganisms. All the extracts inhibited lipid oxidation, except the P. glandulosissimum stem. The plant extracts exhibiting high antioxidant potential (V. baccifera and B. rosademonte) contained high levels of flavanols (particularly, catechin and epicatechin). By contrast, S. grandiflorum leaf, which exhibited very low antioxidant activity, was rich in hydroxycinnamic acids. None of the extracts showed antimicrobial activity. This study demonstrates for the first time the presence of bioactive polyphenolic compounds in several Amazonian plants, and highlights the importance of flavanols as major phenolic contributors to antioxidant activity. |
format | Online Article Text |
id | pubmed-3382806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-33828062012-06-29 Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia Lizcano, Leandro J. Viloria-Bernal, María Vicente, Francisca Berrueta, Luis Angel Gallo, Blanca Martínez-Cañamero, Magdalena Ruiz-Larrea, Maria Begoña Ruiz-Sanz, José Ignacio Int J Mol Sci Article Diverse plants of ethnobotanic interest in Amazonia are commonly used in traditional medicine. We determined the antioxidant potential against lipid peroxidation, the antimicrobial activity, and the polyphenol composition of several Amazonian plants (Brownea rosademonte, Piper glandulosissimum, Piper krukoffii, Piper putumayoense, Solanum grandiflorum, and Vismia baccifera). Extracts from the plant leaf, bark, and stem were prepared as aqueous infusions, as used in folk medicine, and added to rat liver microsomes exposed to iron. The polyphenolic composition was detected by reverse-phase HPLC coupled to diode-array detector and MS/MS analysis. The antimicrobial activity was tested by the spot-on-a-lawn method against several indicator microorganisms. All the extracts inhibited lipid oxidation, except the P. glandulosissimum stem. The plant extracts exhibiting high antioxidant potential (V. baccifera and B. rosademonte) contained high levels of flavanols (particularly, catechin and epicatechin). By contrast, S. grandiflorum leaf, which exhibited very low antioxidant activity, was rich in hydroxycinnamic acids. None of the extracts showed antimicrobial activity. This study demonstrates for the first time the presence of bioactive polyphenolic compounds in several Amazonian plants, and highlights the importance of flavanols as major phenolic contributors to antioxidant activity. Molecular Diversity Preservation International (MDPI) 2012-05-04 /pmc/articles/PMC3382806/ /pubmed/22754307 http://dx.doi.org/10.3390/ijms13055454 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Lizcano, Leandro J. Viloria-Bernal, María Vicente, Francisca Berrueta, Luis Angel Gallo, Blanca Martínez-Cañamero, Magdalena Ruiz-Larrea, Maria Begoña Ruiz-Sanz, José Ignacio Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia |
title | Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia |
title_full | Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia |
title_fullStr | Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia |
title_full_unstemmed | Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia |
title_short | Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia |
title_sort | lipid oxidation inhibitory effects and phenolic composition of aqueous extracts from medicinal plants of colombian amazonia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382806/ https://www.ncbi.nlm.nih.gov/pubmed/22754307 http://dx.doi.org/10.3390/ijms13055454 |
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