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Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis
PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeut...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382846/ https://www.ncbi.nlm.nih.gov/pubmed/22737631 http://dx.doi.org/10.4161/onci.19309 |
| Sumario: | PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeutic agents may have opposing effects on cancer in different cells. |
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