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Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis
PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeut...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382846/ https://www.ncbi.nlm.nih.gov/pubmed/22737631 http://dx.doi.org/10.4161/onci.19309 |
| _version_ | 1782236558465695744 |
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| author | Nemenoff, Raphael |
| author_facet | Nemenoff, Raphael |
| author_sort | Nemenoff, Raphael |
| collection | PubMed |
| description | PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeutic agents may have opposing effects on cancer in different cells. |
| format | Online Article Text |
| id | pubmed-3382846 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33828462012-06-26 Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis Nemenoff, Raphael Oncoimmunology Author's View PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeutic agents may have opposing effects on cancer in different cells. Landes Bioscience 2012-05-01 /pmc/articles/PMC3382846/ /pubmed/22737631 http://dx.doi.org/10.4161/onci.19309 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Nemenoff, Raphael Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis |
| title | Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis |
| title_full | Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis |
| title_fullStr | Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis |
| title_full_unstemmed | Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis |
| title_short | Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis |
| title_sort | activation of pparγ in myeloid cells promotes lung cancer progression and metastasis |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382846/ https://www.ncbi.nlm.nih.gov/pubmed/22737631 http://dx.doi.org/10.4161/onci.19309 |
| work_keys_str_mv | AT nemenoffraphael activationofpparginmyeloidcellspromoteslungcancerprogressionandmetastasis |