Smoothing T cell roads to the tumor: Chemokine post-translational regulation

We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Co...

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Detalles Bibliográficos
Autores principales: Molon, Barbara, Viola, Antonella, Bronte, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382857/
https://www.ncbi.nlm.nih.gov/pubmed/22737626
http://dx.doi.org/10.4161/onci.19069
Descripción
Sumario:We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols.

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