Smoothing T cell roads to the tumor: Chemokine post-translational regulation

We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Co...

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Detalles Bibliográficos
Autores principales: Molon, Barbara, Viola, Antonella, Bronte, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382857/
https://www.ncbi.nlm.nih.gov/pubmed/22737626
http://dx.doi.org/10.4161/onci.19069
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author Molon, Barbara
Viola, Antonella
Bronte, Vincenzo
author_facet Molon, Barbara
Viola, Antonella
Bronte, Vincenzo
author_sort Molon, Barbara
collection PubMed
description We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols.
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spelling pubmed-33828572012-06-26 Smoothing T cell roads to the tumor: Chemokine post-translational regulation Molon, Barbara Viola, Antonella Bronte, Vincenzo Oncoimmunology Author's View We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols. Landes Bioscience 2012-05-01 /pmc/articles/PMC3382857/ /pubmed/22737626 http://dx.doi.org/10.4161/onci.19069 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Molon, Barbara
Viola, Antonella
Bronte, Vincenzo
Smoothing T cell roads to the tumor: Chemokine post-translational regulation
title Smoothing T cell roads to the tumor: Chemokine post-translational regulation
title_full Smoothing T cell roads to the tumor: Chemokine post-translational regulation
title_fullStr Smoothing T cell roads to the tumor: Chemokine post-translational regulation
title_full_unstemmed Smoothing T cell roads to the tumor: Chemokine post-translational regulation
title_short Smoothing T cell roads to the tumor: Chemokine post-translational regulation
title_sort smoothing t cell roads to the tumor: chemokine post-translational regulation
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382857/
https://www.ncbi.nlm.nih.gov/pubmed/22737626
http://dx.doi.org/10.4161/onci.19069
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AT violaantonella smoothingtcellroadstothetumorchemokineposttranslationalregulation
AT brontevincenzo smoothingtcellroadstothetumorchemokineposttranslationalregulation

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