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A molecular profile of T-cell exhaustion in cancer
The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in “exhausted” T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is rev...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382859/ https://www.ncbi.nlm.nih.gov/pubmed/22737618 http://dx.doi.org/10.4161/onci.18342 |
| _version_ | 1782236561387028480 |
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| author | Speiser, Daniel E. |
| author_facet | Speiser, Daniel E. |
| author_sort | Speiser, Daniel E. |
| collection | PubMed |
| description | The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in “exhausted” T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is reversible and limited to anatomical sites of disease. |
| format | Online Article Text |
| id | pubmed-3382859 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33828592012-06-26 A molecular profile of T-cell exhaustion in cancer Speiser, Daniel E. Oncoimmunology Author's View The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in “exhausted” T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is reversible and limited to anatomical sites of disease. Landes Bioscience 2012-05-01 /pmc/articles/PMC3382859/ /pubmed/22737618 http://dx.doi.org/10.4161/onci.18342 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Speiser, Daniel E. A molecular profile of T-cell exhaustion in cancer |
| title | A molecular profile of T-cell exhaustion in cancer |
| title_full | A molecular profile of T-cell exhaustion in cancer |
| title_fullStr | A molecular profile of T-cell exhaustion in cancer |
| title_full_unstemmed | A molecular profile of T-cell exhaustion in cancer |
| title_short | A molecular profile of T-cell exhaustion in cancer |
| title_sort | molecular profile of t-cell exhaustion in cancer |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382859/ https://www.ncbi.nlm.nih.gov/pubmed/22737618 http://dx.doi.org/10.4161/onci.18342 |
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