Cargando…
A molecular profile of T-cell exhaustion in cancer
The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in “exhausted” T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is rev...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382859/ https://www.ncbi.nlm.nih.gov/pubmed/22737618 http://dx.doi.org/10.4161/onci.18342 |