Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis

Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated p...

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Autores principales: Labidi-Galy, Sana Intidhar, Treilleux, Isabelle, Goddard-Leon, Sophie, Combes, Jean-Damien, Blay, Jean-Yves, Ray-Coquard, Isabelle, Caux, Christophe, Bendriss-Vermare, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382863/
https://www.ncbi.nlm.nih.gov/pubmed/22737622
http://dx.doi.org/10.4161/onci.18801
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author Labidi-Galy, Sana Intidhar
Treilleux, Isabelle
Goddard-Leon, Sophie
Combes, Jean-Damien
Blay, Jean-Yves
Ray-Coquard, Isabelle
Caux, Christophe
Bendriss-Vermare, Nathalie
author_facet Labidi-Galy, Sana Intidhar
Treilleux, Isabelle
Goddard-Leon, Sophie
Combes, Jean-Damien
Blay, Jean-Yves
Ray-Coquard, Isabelle
Caux, Christophe
Bendriss-Vermare, Nathalie
author_sort Labidi-Galy, Sana Intidhar
collection PubMed
description Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.
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spelling pubmed-33828632012-06-26 Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis Labidi-Galy, Sana Intidhar Treilleux, Isabelle Goddard-Leon, Sophie Combes, Jean-Damien Blay, Jean-Yves Ray-Coquard, Isabelle Caux, Christophe Bendriss-Vermare, Nathalie Oncoimmunology Author's View Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates. Landes Bioscience 2012-05-01 /pmc/articles/PMC3382863/ /pubmed/22737622 http://dx.doi.org/10.4161/onci.18801 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Labidi-Galy, Sana Intidhar
Treilleux, Isabelle
Goddard-Leon, Sophie
Combes, Jean-Damien
Blay, Jean-Yves
Ray-Coquard, Isabelle
Caux, Christophe
Bendriss-Vermare, Nathalie
Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
title Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
title_full Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
title_fullStr Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
title_full_unstemmed Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
title_short Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
title_sort plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382863/
https://www.ncbi.nlm.nih.gov/pubmed/22737622
http://dx.doi.org/10.4161/onci.18801
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