The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects

The use of immunotherapy to treat cancer is rapidly gaining momentum. Using pre-clinical mouse models, we have recently demonstrated potent and long lasting tumor regression can be elicited by immune-stimulating monoclonal antibodies (mAbs) when combined with histone deacetylase inhibitors (HDACi) a...

Descripción completa

Detalles Bibliográficos
Autores principales: West, Alison C., Christiansen, Ailsa J., Smyth, Mark J., Johnstone, Ricky W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382866/
https://www.ncbi.nlm.nih.gov/pubmed/22737621
http://dx.doi.org/10.4161/onci.18804
_version_ 1782236562964086784
author West, Alison C.
Christiansen, Ailsa J.
Smyth, Mark J.
Johnstone, Ricky W.
author_facet West, Alison C.
Christiansen, Ailsa J.
Smyth, Mark J.
Johnstone, Ricky W.
author_sort West, Alison C.
collection PubMed
description The use of immunotherapy to treat cancer is rapidly gaining momentum. Using pre-clinical mouse models, we have recently demonstrated potent and long lasting tumor regression can be elicited by immune-stimulating monoclonal antibodies (mAbs) when combined with histone deacetylase inhibitors (HDACi) and believe this therapy will have broad application in humans.
format Online
Article
Text
id pubmed-3382866
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-33828662012-06-26 The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects West, Alison C. Christiansen, Ailsa J. Smyth, Mark J. Johnstone, Ricky W. Oncoimmunology Author's View The use of immunotherapy to treat cancer is rapidly gaining momentum. Using pre-clinical mouse models, we have recently demonstrated potent and long lasting tumor regression can be elicited by immune-stimulating monoclonal antibodies (mAbs) when combined with histone deacetylase inhibitors (HDACi) and believe this therapy will have broad application in humans. Landes Bioscience 2012-05-01 /pmc/articles/PMC3382866/ /pubmed/22737621 http://dx.doi.org/10.4161/onci.18804 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
West, Alison C.
Christiansen, Ailsa J.
Smyth, Mark J.
Johnstone, Ricky W.
The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
title The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
title_full The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
title_fullStr The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
title_full_unstemmed The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
title_short The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
title_sort combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382866/
https://www.ncbi.nlm.nih.gov/pubmed/22737621
http://dx.doi.org/10.4161/onci.18804
work_keys_str_mv AT westalisonc thecombinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects
AT christiansenailsaj thecombinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects
AT smythmarkj thecombinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects
AT johnstonerickyw thecombinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects
AT westalisonc combinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects
AT christiansenailsaj combinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects
AT smythmarkj combinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects
AT johnstonerickyw combinationofhistonedeacetylaseinhibitorswithimmunestimulatingantibodieshaspotentanticancereffects

Ejemplares similares