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DNA vaccination against oncoantigens: A promise
The emerging evidence that DNA vaccines elicit a protective immune response in rodents, dogs and cancer patients, coupled with the US Food and Drug Administration (FDA) approval of an initial DNA vaccine to treat canine tumors is beginning to close the gap between the optimistic experimental data an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382874/ https://www.ncbi.nlm.nih.gov/pubmed/22737607 http://dx.doi.org/10.4161/onci.19127 |
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author | Iezzi, Manuela Quaglino, Elena Amici, Augusto Lollini, Pier-Luigi Forni, Guido Cavallo, Federica |
author_facet | Iezzi, Manuela Quaglino, Elena Amici, Augusto Lollini, Pier-Luigi Forni, Guido Cavallo, Federica |
author_sort | Iezzi, Manuela |
collection | PubMed |
description | The emerging evidence that DNA vaccines elicit a protective immune response in rodents, dogs and cancer patients, coupled with the US Food and Drug Administration (FDA) approval of an initial DNA vaccine to treat canine tumors is beginning to close the gap between the optimistic experimental data and their difficult application in a clinical setting. Here we review a series of conceptual and biotechnological advances that are working together to make DNA vaccines targeting molecules that play important roles during cancer progression (oncoantigens) a promise with near-term clinical impact. |
format | Online Article Text |
id | pubmed-3382874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-33828742012-06-26 DNA vaccination against oncoantigens: A promise Iezzi, Manuela Quaglino, Elena Amici, Augusto Lollini, Pier-Luigi Forni, Guido Cavallo, Federica Oncoimmunology Review The emerging evidence that DNA vaccines elicit a protective immune response in rodents, dogs and cancer patients, coupled with the US Food and Drug Administration (FDA) approval of an initial DNA vaccine to treat canine tumors is beginning to close the gap between the optimistic experimental data and their difficult application in a clinical setting. Here we review a series of conceptual and biotechnological advances that are working together to make DNA vaccines targeting molecules that play important roles during cancer progression (oncoantigens) a promise with near-term clinical impact. Landes Bioscience 2012-05-01 /pmc/articles/PMC3382874/ /pubmed/22737607 http://dx.doi.org/10.4161/onci.19127 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Iezzi, Manuela Quaglino, Elena Amici, Augusto Lollini, Pier-Luigi Forni, Guido Cavallo, Federica DNA vaccination against oncoantigens: A promise |
title | DNA vaccination against oncoantigens: A promise |
title_full | DNA vaccination against oncoantigens: A promise |
title_fullStr | DNA vaccination against oncoantigens: A promise |
title_full_unstemmed | DNA vaccination against oncoantigens: A promise |
title_short | DNA vaccination against oncoantigens: A promise |
title_sort | dna vaccination against oncoantigens: a promise |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382874/ https://www.ncbi.nlm.nih.gov/pubmed/22737607 http://dx.doi.org/10.4161/onci.19127 |
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