Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy

Radiotherapy applies ionizing irradiation to selected areas of the body with the scope of destroying cancer cells, either as part of curative therapies to remove a primary malignant tumor and to prevent tumor recurrence after surgery, or as part of palliative measures to avoid local advancement of b...

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Detalles Bibliográficos
Autores principales: Kroemer, Guido, Zitvogel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Editor's Corner
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382878/
https://www.ncbi.nlm.nih.gov/pubmed/22754758
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author Kroemer, Guido
Zitvogel, Laurence
author_facet Kroemer, Guido
Zitvogel, Laurence
author_sort Kroemer, Guido
collection PubMed
description Radiotherapy applies ionizing irradiation to selected areas of the body with the scope of destroying cancer cells, either as part of curative therapies to remove a primary malignant tumor and to prevent tumor recurrence after surgery, or as part of palliative measures to avoid local advancement of bone and brain metastases. Intriguingly, radiotherapy does not only have local effects but may lead to the delayed regression of distant non-irradiated lesions. Most likely, these “abscopal” effects are mediated by the immune system.
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spelling pubmed-33828782012-07-01 Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy Kroemer, Guido Zitvogel, Laurence Oncoimmunology Editor's Corner Radiotherapy applies ionizing irradiation to selected areas of the body with the scope of destroying cancer cells, either as part of curative therapies to remove a primary malignant tumor and to prevent tumor recurrence after surgery, or as part of palliative measures to avoid local advancement of bone and brain metastases. Intriguingly, radiotherapy does not only have local effects but may lead to the delayed regression of distant non-irradiated lesions. Most likely, these “abscopal” effects are mediated by the immune system. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382878/ /pubmed/22754758 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Editor's Corner
Kroemer, Guido
Zitvogel, Laurence
Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy
title Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy
title_full Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy
title_fullStr Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy
title_full_unstemmed Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy
title_short Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy
title_sort abscopal but desirable: the contribution of immune responses to the efficacy of radiotherapy
topic Editor's Corner
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382878/
https://www.ncbi.nlm.nih.gov/pubmed/22754758
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