Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression

Myeloid-derived suppressor cells (MDSC) induced during neoplasia display potent pro-tumorigenic activities. Tumor-derived factors influence MDSC development, yielding monocytic and granulocytic subsets. In contrast to monocytic MDSC, little is known about how granulocytic MDSC develop. We demonstrat...

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Detalles Bibliográficos
Autores principales: Abrams, Scott I., Waight, Jeremy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382879/
https://www.ncbi.nlm.nih.gov/pubmed/22754783
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author Abrams, Scott I.
Waight, Jeremy D.
author_facet Abrams, Scott I.
Waight, Jeremy D.
author_sort Abrams, Scott I.
collection PubMed
description Myeloid-derived suppressor cells (MDSC) induced during neoplasia display potent pro-tumorigenic activities. Tumor-derived factors influence MDSC development, yielding monocytic and granulocytic subsets. In contrast to monocytic MDSC, little is known about how granulocytic MDSC develop. We demonstrated that tumor-derived G-CSF drives granulocytic MDSC formation, thus providing new insights into myeloid-tumor biology.
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spelling pubmed-33828792012-07-01 Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression Abrams, Scott I. Waight, Jeremy D. Oncoimmunology Author's View Myeloid-derived suppressor cells (MDSC) induced during neoplasia display potent pro-tumorigenic activities. Tumor-derived factors influence MDSC development, yielding monocytic and granulocytic subsets. In contrast to monocytic MDSC, little is known about how granulocytic MDSC develop. We demonstrated that tumor-derived G-CSF drives granulocytic MDSC formation, thus providing new insights into myeloid-tumor biology. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382879/ /pubmed/22754783 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Abrams, Scott I.
Waight, Jeremy D.
Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression
title Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression
title_full Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression
title_fullStr Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression
title_full_unstemmed Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression
title_short Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression
title_sort identification of a g-csf-granulocytic mdsc axis that promotes tumor progression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382879/
https://www.ncbi.nlm.nih.gov/pubmed/22754783
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AT waightjeremyd identificationofagcsfgranulocyticmdscaxisthatpromotestumorprogression

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