Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer

The immune interactions occurring within the tumor microenvironment have a critical role in determining the outcome of colorectal cancer patients. We carried-out an immunohistochemical analysis of tumor infiltrating T-lymphocytes expressing chemokine receptor 7 (CCR7) in a series of colorectal cance...

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Autores principales: Correale, Pierpaolo, Rotundo, Maria Saveria, Botta, Cirino, Del Vecchio, Maria Teresa, Tassone, Pierfrancesco, Tagliaferri, Pierosandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382880/
https://www.ncbi.nlm.nih.gov/pubmed/22754775
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author Correale, Pierpaolo
Rotundo, Maria Saveria
Botta, Cirino
Del Vecchio, Maria Teresa
Tassone, Pierfrancesco
Tagliaferri, Pierosandro
author_facet Correale, Pierpaolo
Rotundo, Maria Saveria
Botta, Cirino
Del Vecchio, Maria Teresa
Tassone, Pierfrancesco
Tagliaferri, Pierosandro
author_sort Correale, Pierpaolo
collection PubMed
description The immune interactions occurring within the tumor microenvironment have a critical role in determining the outcome of colorectal cancer patients. We carried-out an immunohistochemical analysis of tumor infiltrating T-lymphocytes expressing chemokine receptor 7 (CCR7) in a series of colorectal cancer patients enrolled in a prospective clinical trial. We demonstrated that a high tumor infiltration score of this lymphocyte subset is predictive of longer progression free survival and overall survival.
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spelling pubmed-33828802012-07-01 Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer Correale, Pierpaolo Rotundo, Maria Saveria Botta, Cirino Del Vecchio, Maria Teresa Tassone, Pierfrancesco Tagliaferri, Pierosandro Oncoimmunology Author's View The immune interactions occurring within the tumor microenvironment have a critical role in determining the outcome of colorectal cancer patients. We carried-out an immunohistochemical analysis of tumor infiltrating T-lymphocytes expressing chemokine receptor 7 (CCR7) in a series of colorectal cancer patients enrolled in a prospective clinical trial. We demonstrated that a high tumor infiltration score of this lymphocyte subset is predictive of longer progression free survival and overall survival. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382880/ /pubmed/22754775 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Correale, Pierpaolo
Rotundo, Maria Saveria
Botta, Cirino
Del Vecchio, Maria Teresa
Tassone, Pierfrancesco
Tagliaferri, Pierosandro
Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
title Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
title_full Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
title_fullStr Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
title_full_unstemmed Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
title_short Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
title_sort tumor infiltration by chemokine receptor 7 (ccr7)(+) t-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382880/
https://www.ncbi.nlm.nih.gov/pubmed/22754775
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