Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?

We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and...

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Detalles Bibliográficos
Autores principales: Facciabene, Andrea, Santoro, Stephen, Coukos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382887/
https://www.ncbi.nlm.nih.gov/pubmed/22754792
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author Facciabene, Andrea
Santoro, Stephen
Coukos, George
author_facet Facciabene, Andrea
Santoro, Stephen
Coukos, George
author_sort Facciabene, Andrea
collection PubMed
description We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and discuss the challenges and opportunities for therapy targeting Treg.
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spelling pubmed-33828872012-07-01 Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious? Facciabene, Andrea Santoro, Stephen Coukos, George Oncoimmunology Author's View We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and discuss the challenges and opportunities for therapy targeting Treg. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382887/ /pubmed/22754792 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Facciabene, Andrea
Santoro, Stephen
Coukos, George
Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
title Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
title_full Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
title_fullStr Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
title_full_unstemmed Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
title_short Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
title_sort know thy enemy: why are tumor-infiltrating regulatory t cells so deleterious?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382887/
https://www.ncbi.nlm.nih.gov/pubmed/22754792
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AT santorostephen knowthyenemywhyaretumorinfiltratingregulatorytcellssodeleterious
AT coukosgeorge knowthyenemywhyaretumorinfiltratingregulatorytcellssodeleterious

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