The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells

Metastasis is strongly inhibited in thrombocytopenic mice. This phenotype is reversed by NK cell depletion which indicates that platelets may facilitate tumor progression and metastasis by interfering with NK cell immunosurveillance. Understanding the underlying mechanisms may help us to reinforce a...

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Detalles Bibliográficos
Autores principales: Placke, Theresa, Kopp, Hans-Georg, Salih, Helmut Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382889/
https://www.ncbi.nlm.nih.gov/pubmed/22754786
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author Placke, Theresa
Kopp, Hans-Georg
Salih, Helmut Rainer
author_facet Placke, Theresa
Kopp, Hans-Georg
Salih, Helmut Rainer
author_sort Placke, Theresa
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description Metastasis is strongly inhibited in thrombocytopenic mice. This phenotype is reversed by NK cell depletion which indicates that platelets may facilitate tumor progression and metastasis by interfering with NK cell immunosurveillance. Understanding the underlying mechanisms may help us to reinforce anti-tumor immunity and NK-based immunotherapy in cancer patients.
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spelling pubmed-33828892012-07-01 The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells Placke, Theresa Kopp, Hans-Georg Salih, Helmut Rainer Oncoimmunology Author's View Metastasis is strongly inhibited in thrombocytopenic mice. This phenotype is reversed by NK cell depletion which indicates that platelets may facilitate tumor progression and metastasis by interfering with NK cell immunosurveillance. Understanding the underlying mechanisms may help us to reinforce anti-tumor immunity and NK-based immunotherapy in cancer patients. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382889/ /pubmed/22754786 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Placke, Theresa
Kopp, Hans-Georg
Salih, Helmut Rainer
The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells
title The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells
title_full The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells
title_fullStr The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells
title_full_unstemmed The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells
title_short The wolf in sheep’s clothing: Platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by NK cells
title_sort wolf in sheep’s clothing: platelet-derived “pseudo self” impairs cancer cell “missing self” recognition by nk cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382889/
https://www.ncbi.nlm.nih.gov/pubmed/22754786
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