Engineering hematopoietic stem cells to create melanoma specific CTL

Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated th...

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Detalles Bibliográficos
Autor principal: Vatakis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382894/
https://www.ncbi.nlm.nih.gov/pubmed/22754779
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author Vatakis, Dimitrios
author_facet Vatakis, Dimitrios
author_sort Vatakis, Dimitrios
collection PubMed
description Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated the bone marrow.
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spelling pubmed-33828942012-07-01 Engineering hematopoietic stem cells to create melanoma specific CTL Vatakis, Dimitrios Oncoimmunology Author's View Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated the bone marrow. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382894/ /pubmed/22754779 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Vatakis, Dimitrios
Engineering hematopoietic stem cells to create melanoma specific CTL
title Engineering hematopoietic stem cells to create melanoma specific CTL
title_full Engineering hematopoietic stem cells to create melanoma specific CTL
title_fullStr Engineering hematopoietic stem cells to create melanoma specific CTL
title_full_unstemmed Engineering hematopoietic stem cells to create melanoma specific CTL
title_short Engineering hematopoietic stem cells to create melanoma specific CTL
title_sort engineering hematopoietic stem cells to create melanoma specific ctl
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382894/
https://www.ncbi.nlm.nih.gov/pubmed/22754779
work_keys_str_mv AT vatakisdimitrios engineeringhematopoieticstemcellstocreatemelanomaspecificctl

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