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Engineering hematopoietic stem cells to create melanoma specific CTL
Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382894/ https://www.ncbi.nlm.nih.gov/pubmed/22754779 |