CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection

We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of...

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Detalles Bibliográficos
Autores principales: Waitz, Rebecca, Fassò, Marcella, Allison, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382897/
https://www.ncbi.nlm.nih.gov/pubmed/22754781
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author Waitz, Rebecca
Fassò, Marcella
Allison, James P.
author_facet Waitz, Rebecca
Fassò, Marcella
Allison, James P.
author_sort Waitz, Rebecca
collection PubMed
description We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.
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spelling pubmed-33828972012-07-01 CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection Waitz, Rebecca Fassò, Marcella Allison, James P. Oncoimmunology Author's View We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382897/ /pubmed/22754781 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Waitz, Rebecca
Fassò, Marcella
Allison, James P.
CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
title CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
title_full CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
title_fullStr CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
title_full_unstemmed CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
title_short CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
title_sort ctla-4 blockade synergizes with cryoablation to mediate tumor rejection
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382897/
https://www.ncbi.nlm.nih.gov/pubmed/22754781
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AT allisonjamesp ctla4blockadesynergizeswithcryoablationtomediatetumorrejection

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