A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor ce...

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Autores principales: Rosental, Benyamin, Hadad, Uzi, Brusilovsky, Michael, Campbell, Kerry S., Porgador, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382898/
https://www.ncbi.nlm.nih.gov/pubmed/22754791
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author Rosental, Benyamin
Hadad, Uzi
Brusilovsky, Michael
Campbell, Kerry S.
Porgador, Angel
author_facet Rosental, Benyamin
Hadad, Uzi
Brusilovsky, Michael
Campbell, Kerry S.
Porgador, Angel
author_sort Rosental, Benyamin
collection PubMed
description We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.
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spelling pubmed-33828982012-07-01 A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen Rosental, Benyamin Hadad, Uzi Brusilovsky, Michael Campbell, Kerry S. Porgador, Angel Oncoimmunology Author's View We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382898/ /pubmed/22754791 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Rosental, Benyamin
Hadad, Uzi
Brusilovsky, Michael
Campbell, Kerry S.
Porgador, Angel
A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen
title A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen
title_full A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen
title_fullStr A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen
title_full_unstemmed A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen
title_short A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen
title_sort novel mechanism for cancer cells to evade immune attack by nk cells: the interaction between nkp44 and proliferating cell nuclear antigen
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382898/
https://www.ncbi.nlm.nih.gov/pubmed/22754791
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