OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T cells

Adoptive therapy with chimeric antigen receptor (CAR) redirected T cells recently showed remarkable anti-tumor efficacy in early phase clinical trials; self-repression of the immune response by T-cell secreted cytokines, however, is still an issue raising interest to abrogate the secretion of repres...

Descripción completa

Detalles Bibliográficos
Autores principales: Hombach, Andreas A., Heiders, Johannes, Foppe, Marcel, Chmielewski, Markus, Abken, Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382912/
https://www.ncbi.nlm.nih.gov/pubmed/22754764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382912/
https://www.ncbi.nlm.nih.gov/pubmed/22754764

Ejemplares similares