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How Do Cytokines Trigger Genomic Instability?
Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382994/ https://www.ncbi.nlm.nih.gov/pubmed/22754280 http://dx.doi.org/10.1155/2012/536761 |
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author | Aivaliotis, Ioannis L. Pateras, Ioannis S. Papaioannou, Marilena Glytsou, Christina Kontzoglou, Konstantinos Johnson, Elizabeth O. Zoumpourlis, Vassilis |
author_facet | Aivaliotis, Ioannis L. Pateras, Ioannis S. Papaioannou, Marilena Glytsou, Christina Kontzoglou, Konstantinos Johnson, Elizabeth O. Zoumpourlis, Vassilis |
author_sort | Aivaliotis, Ioannis L. |
collection | PubMed |
description | Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer. |
format | Online Article Text |
id | pubmed-3382994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33829942012-06-29 How Do Cytokines Trigger Genomic Instability? Aivaliotis, Ioannis L. Pateras, Ioannis S. Papaioannou, Marilena Glytsou, Christina Kontzoglou, Konstantinos Johnson, Elizabeth O. Zoumpourlis, Vassilis J Biomed Biotechnol Review Article Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer. Hindawi Publishing Corporation 2012 2012-06-17 /pmc/articles/PMC3382994/ /pubmed/22754280 http://dx.doi.org/10.1155/2012/536761 Text en Copyright © 2012 Ioannis L. Aivaliotis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Aivaliotis, Ioannis L. Pateras, Ioannis S. Papaioannou, Marilena Glytsou, Christina Kontzoglou, Konstantinos Johnson, Elizabeth O. Zoumpourlis, Vassilis How Do Cytokines Trigger Genomic Instability? |
title | How Do Cytokines Trigger Genomic Instability? |
title_full | How Do Cytokines Trigger Genomic Instability? |
title_fullStr | How Do Cytokines Trigger Genomic Instability? |
title_full_unstemmed | How Do Cytokines Trigger Genomic Instability? |
title_short | How Do Cytokines Trigger Genomic Instability? |
title_sort | how do cytokines trigger genomic instability? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382994/ https://www.ncbi.nlm.nih.gov/pubmed/22754280 http://dx.doi.org/10.1155/2012/536761 |
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