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In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox
The effect of whole leaf and gel materials from two aloe species (Aloe vera and A. ferox) was compared with that of the precipitated polysaccharides from these aloe materials on the transepithelial electrical resistance (TEER) as well as transport of a model compound (atenolol) in the apical-to-baso...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Österreichische Apotheker-Verlagsgesellschaft
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383217/ https://www.ncbi.nlm.nih.gov/pubmed/22896832 http://dx.doi.org/10.3797/scipharm.1202-10 |
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author | Beneke, Catharina Viljoen, Alvaro Hamman, Josias |
author_facet | Beneke, Catharina Viljoen, Alvaro Hamman, Josias |
author_sort | Beneke, Catharina |
collection | PubMed |
description | The effect of whole leaf and gel materials from two aloe species (Aloe vera and A. ferox) was compared with that of the precipitated polysaccharides from these aloe materials on the transepithelial electrical resistance (TEER) as well as transport of a model compound (atenolol) in the apical-to-basolateral direction across rat intestinal tissue. All the aloe leaf materials and precipitated polysaccharides had a statistically significant effect of lowering the TEER (P < 0.05) compared to the control group, which indicates their ability to open tight junctions between adjacent epithelial cells. In contrast to the expectation from the TEER results, only the precipitated polysaccharides from dehydrated A. vera gel (Daltonmax 700(®)) had a statistically significant effect of enhancing the transport of atenolol (P < 0.05). These in vitro results therefore indicate that A. vera gel polysaccharides have potential as drug absorption enhancing agents in novel pharmaceutical drug delivery systems. |
format | Online Article Text |
id | pubmed-3383217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Österreichische Apotheker-Verlagsgesellschaft |
record_format | MEDLINE/PubMed |
spelling | pubmed-33832172012-08-15 In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox Beneke, Catharina Viljoen, Alvaro Hamman, Josias Sci Pharm Research Article The effect of whole leaf and gel materials from two aloe species (Aloe vera and A. ferox) was compared with that of the precipitated polysaccharides from these aloe materials on the transepithelial electrical resistance (TEER) as well as transport of a model compound (atenolol) in the apical-to-basolateral direction across rat intestinal tissue. All the aloe leaf materials and precipitated polysaccharides had a statistically significant effect of lowering the TEER (P < 0.05) compared to the control group, which indicates their ability to open tight junctions between adjacent epithelial cells. In contrast to the expectation from the TEER results, only the precipitated polysaccharides from dehydrated A. vera gel (Daltonmax 700(®)) had a statistically significant effect of enhancing the transport of atenolol (P < 0.05). These in vitro results therefore indicate that A. vera gel polysaccharides have potential as drug absorption enhancing agents in novel pharmaceutical drug delivery systems. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-04-01 /pmc/articles/PMC3383217/ /pubmed/22896832 http://dx.doi.org/10.3797/scipharm.1202-10 Text en © Beneke et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Beneke, Catharina Viljoen, Alvaro Hamman, Josias In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox |
title | In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox |
title_full | In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox |
title_fullStr | In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox |
title_full_unstemmed | In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox |
title_short | In Vitro Drug Absorption Enhancement Effects of Aloe vera and Aloe ferox |
title_sort | in vitro drug absorption enhancement effects of aloe vera and aloe ferox |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383217/ https://www.ncbi.nlm.nih.gov/pubmed/22896832 http://dx.doi.org/10.3797/scipharm.1202-10 |
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