Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions

Artemisia herba-alba Asso. is a shrub commonly encountered in Morocco. It is used in traditional medicine for treating intestinal disorders. The essential oil extracted from the plant’s aerial parts reversibly relaxed the spontaneous tonus of the rabbit jejunum in a reversible concentration dependen...

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Autores principales: Aziz, Mohammed, Karim, Ahmed, El Ouariachi, El Mokhtar, Bouyanzer, Abdelhamid, Amrani, Souliman, Mekhfi, Hassane, Ziyyat, Abderrahim, Melhaoui, Ahmed, Bnouham, Mohamed, Legssyer, Abdelkhaleq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383221/
https://www.ncbi.nlm.nih.gov/pubmed/22896830
http://dx.doi.org/10.3797/scipharm.1106-13
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author Aziz, Mohammed
Karim, Ahmed
El Ouariachi, El Mokhtar
Bouyanzer, Abdelhamid
Amrani, Souliman
Mekhfi, Hassane
Ziyyat, Abderrahim
Melhaoui, Ahmed
Bnouham, Mohamed
Legssyer, Abdelkhaleq
author_facet Aziz, Mohammed
Karim, Ahmed
El Ouariachi, El Mokhtar
Bouyanzer, Abdelhamid
Amrani, Souliman
Mekhfi, Hassane
Ziyyat, Abderrahim
Melhaoui, Ahmed
Bnouham, Mohamed
Legssyer, Abdelkhaleq
author_sort Aziz, Mohammed
collection PubMed
description Artemisia herba-alba Asso. is a shrub commonly encountered in Morocco. It is used in traditional medicine for treating intestinal disorders. The essential oil extracted from the plant’s aerial parts reversibly relaxed the spontaneous tonus of the rabbit jejunum in a reversible concentration dependent manner with an IC(50) value of 97.33 ± 2.59 ng/ml and reversed the tonic contraction of rat jejunum induced by 75 mM KCl and 10(−6) M carbachol with IC(50) values of 115.5 ± 3.05 and 119.4 ± 20.86 ng/ml, respectively. The pre-treatment of the latter isolated intestine with this essential oil produced a dose-dependent shift of the Ca(++) and CCh dose-response curve to the right, with suppression of the maximal effect, similar to the non-competitive antagonist effect on muscarinic receptors and calcium channel, respectively.
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spelling pubmed-33832212012-08-15 Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions Aziz, Mohammed Karim, Ahmed El Ouariachi, El Mokhtar Bouyanzer, Abdelhamid Amrani, Souliman Mekhfi, Hassane Ziyyat, Abderrahim Melhaoui, Ahmed Bnouham, Mohamed Legssyer, Abdelkhaleq Sci Pharm Research Article Artemisia herba-alba Asso. is a shrub commonly encountered in Morocco. It is used in traditional medicine for treating intestinal disorders. The essential oil extracted from the plant’s aerial parts reversibly relaxed the spontaneous tonus of the rabbit jejunum in a reversible concentration dependent manner with an IC(50) value of 97.33 ± 2.59 ng/ml and reversed the tonic contraction of rat jejunum induced by 75 mM KCl and 10(−6) M carbachol with IC(50) values of 115.5 ± 3.05 and 119.4 ± 20.86 ng/ml, respectively. The pre-treatment of the latter isolated intestine with this essential oil produced a dose-dependent shift of the Ca(++) and CCh dose-response curve to the right, with suppression of the maximal effect, similar to the non-competitive antagonist effect on muscarinic receptors and calcium channel, respectively. Österreichische Apotheker-Verlagsgesellschaft 2012 2012-01-12 /pmc/articles/PMC3383221/ /pubmed/22896830 http://dx.doi.org/10.3797/scipharm.1106-13 Text en © Aziz et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aziz, Mohammed
Karim, Ahmed
El Ouariachi, El Mokhtar
Bouyanzer, Abdelhamid
Amrani, Souliman
Mekhfi, Hassane
Ziyyat, Abderrahim
Melhaoui, Ahmed
Bnouham, Mohamed
Legssyer, Abdelkhaleq
Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions
title Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions
title_full Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions
title_fullStr Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions
title_full_unstemmed Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions
title_short Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions
title_sort relaxant effect of essential oil of artemisia herba-alba asso. on rodent jejunum contractions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383221/
https://www.ncbi.nlm.nih.gov/pubmed/22896830
http://dx.doi.org/10.3797/scipharm.1106-13
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