NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo

Drug release rate is an important factor in determining efficacy and toxicity of nanoscale drug delivery systems. However, optimization of the release rate in polymeric micellar nanoscale drug delivery systems has not been fully investigated. In this study NC-6301, a poly(ethylene glycol)-poly(aspar...

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Detalles Bibliográficos
Autores principales: Harada, Mitsunori, Iwata, Caname, Saito, Hiroyuki, Ishii, Kenta, Hayashi, Tatsuyuki, Yashiro, Masakazu, Hirakawa, Kosei, Miyazono, Kohei, Kato, Yasuki, Kano, Mitsunobu R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383288/
https://www.ncbi.nlm.nih.gov/pubmed/22745540
http://dx.doi.org/10.2147/IJN.S31247

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